![]() ( Shutterstock, Helen Sushitskaya)Īn NCATS-led Rare Diseases Clinical Research Network consortium charted the course of the disorders, developed lifesaving therapies and pioneered a screening test for newborns Jude press release about the study.Primary Immune Deficiency Treatment Consortium researchers showed that newborn screening for severe combined immunodeficiency, a rare, life-threatening immune disorder, led to earlier treatment and saved lives. The biopharmaceutical company Mustang Bio is developing the lentivirus gene therapy technique for commercial use.Ĭlick here for the St. With further research, a similar approach might be used to cure sickle cell disease and other blood disorders. This is a first for patients with SCID-X1,” Mamcarz said in a St. “These patients are toddlers now, who are responding to vaccinations and have immune systems make all immune cells they need for protection from infections as they explore the world and live normal lives. In some prior studies, less precise gene therapy vectors have activated nearby oncogenes (cancer-causing genes), leading to the development of leukemia, but that has not been observed in this study. Importantly, the viral vector used in this study included “insulators” to block activation of adjacent genes. The researchers added that the treatment was generally safe, with no unexpected side effects, and the low-dose chemotherapy regimen was well tolerated. The treatment appears to be long-lasting, with the longest follow-up exceeding two years. Three of these children were able to mount responses to vaccines, showing that their new immune cells could recognize and respond to invaders.Īll the children cleared preexisting infections, most were able to leave the hospital with a month, none have developed new severe infections since receiving the gene therapy and they are growing normally, the researchers reported. Seven children reached normal IgM antibody levels and four no longer needed antibody replacement therapy. The remaining child responded after a second booster infusion. Within three to four months after infusion of the genetically altered stem cells, seven of the children reached normal levels of T cells and natural killer cells and began producing functional B cells, which produce antibodies. ![]() After bone marrow samples were collected, the children were treated with a conditioning regimen using a low dose of the chemotherapy drug busulfan to make room in the bone marrow for reintroduction of the engineered stem cells. ![]() Jude Hospital or UCSF Benioff Children’s Hospital in San Francisco. This study included eight infants treated at St. Lentiviruses like HIV make good vectors for gene therapy because they can integrate themselves into host cell chromosomes-which is what makes HIV so difficult to cure. The best treatment is a bone marrow stem cell transplant from a genetically matched sibling, but most affected children don’t have a suitable donor.Įwelina Mamcarz, MD, and colleagues used inactivated HIV to carry normal IL2RG DNA into hematopoietic (blood-forming) stem cells, which give rise to all immune cells. Without treatment, children born with the condition usually die at a young age. It is caused by a mutation in the IL2RG (interleukin-2 receptor subunit gamma) gene, which produces a piece of several interleukin proteins required for normal immune function. SCID-X1 is a rare, life-threatening genetic disorder occurring in about 1 in 200,000 infants. Within months after receiving stem cells repaired with gene therapy, children in a Phase I/II clinical trial had functioning immune systems with working T cells, B cells and natural killer cells, according to a recent report in The New England Journal of Medicine. Jude Children’s Research Hospital in Memphis tested the experimental approach in eight infants with severe combined immunodeficiency (SCID)-a condition known as “bubble boy” disease because affected individuals cannot fight off germs and must live in an isolated environment to protect them from deadly infections. HIV is well known for causing immune deficiency, but in a new twist, researchers have used a disabled form of the virus to deliver gene therapy that successfully treated children with inherited immune system impairment.
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Fill out the form by clicking on the picture of the computer screen with our logo on it. “Like other shelters, ours deals with a large population of homeless pets, and animals from these cases present unique challenges given their severe medical and behavioral issues and the costs associated with those.We are an all-volunteer/foster home-based rescue.Īpply to adopt by filling out the online adoption application on our main website Ĭlick on Adoption Info under the Navigation bar on the left side of the page. “Shelters like ours are often tasked with cleaning up the USDA's mess when they fail to enforce the law," explains Tom Colvin, CEO of the ARL, which also employs a full-time Animal Welfare Intervention Coordinator who works with law enforcement across the state on cruelty, hoarding and puppy mill cases. “Thousands of other dogs are still living in horrific conditions without adequate access to food, water, veterinary care and exercise, while the USDA stands idly by, allowing violations to go unreported and unpunished.”īy helping protect animals in commercial breeding facilities, Goldie’s Act would also support local shelters. "Goldie was left to endure prolonged and extreme suffering, and her tragic death is a direct result of the USDA’s failure to fulfill its responsibility under the law to protect dogs who are bred and warehoused for the pet trade,” said Matt Bershadker, CEO of the ASPCA,which strongly supports Goldie’s Act. She died at the breeding facility after suffering months of extreme neglect. ![]() Goldie, for whom the bill was named, was a Golden Retriever raised in the same facility as Roxie. Cindy Axne (D-Iowa), Brian Fitzpatrick (R-Pa.), Mike Quigley (D-Ill.), Nicole Malliotakis (R-N.Y.), Susan Wild (D-Pa.) and Vern Buchanan (R-Fla.) introduced Goldie’s Act, a federal bill to amend the Animal Welfare Act (AWA) to ensure it better protects dogs in breeding facilities. 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Sometimes you wanna punch life in the gonads but then it shoryukens your ass and makes you look like a noob -3. Doing papers and such at school is a real pain in the ass no?Įspecially end of the year crap like projects, presentations, deadlines all that nasty jazz. ![]() La emisión de las antenas fotoconductoras puede mejorarse optimizando estos parámetros. Los resultados de la simulación demuestran cómo estos parámetros inciden en la fotocorriente generada y en la frecuencia de radiación THz: la abertura fotoconductora (la separación de los electrodos metálicos de la antena), la potencia promedio del láser incidente y el voltaje de polarización, determinan la forma de onda de la fotocorriente generada mientras que la longitud del dipolo determina la frecuencia de radiación. Los principales parámetros de las antenas fotoconductoras empleadas como emisores de THz son estudiados. En el presente artículo se propone una simulación Multi-Física para integrar estos fenómenos utilizando COMSOL Multiphysics 4.3b. La emisión de Terahertz (THz) empleando antenas fotoconductoras representa un reto de simulación en la integración de los fenómenos de transporte en semiconductores, de óptica y de transporte de energía por radiación THz. Keywords: Multi-physics simulation, photoconductive antennas, semiconductor physics, electromagnetics. The simulations extend the advance of compact and cost-effective THz emitters. The optimization of these parameters could enhance the emission. The results indicate the role of each parameter in the resulting photocurrent waveform and THz frequency: The radiated THz photocurrent waveform is determined by the photoconductive gap (the separation between the metallic electrodes), the incident laser illumination and the DC excitation voltage while the THz frequency depends on the dipole length. The main parameters of THz photoconductive (PC) antenna as THz emitter have been reviewed and discussed. In this paper a Multi-physics simulation for coupling these phenomena using COMSOL Multi-physics 4.3b is introduced. Simulation of terahertz (THz) emission based on PC antennas imposes a challenge to couple the semiconductor carrier phenomena, optical transport and the THz energy transport. Simulation of photoconductive antennas for terahertz radiation. Affiliation: Associated Professor, Universidad de los Andes, Colombia.Į-mail: to cite: Criollo, C., & Ávila, A. Masters in Microelectronics, Physicist and Electronic Engineer, Universidad de los Andes, Colombia. in Physics, Cambridge University, United Kingdom. Affiliation: Research assistant in Microelectronics Research Center (CMUA), Universidad de los Andes, Colombia. in Micro-electronics, Universidad de los Andes, Colombia. Electronic Engineer, Universidad de Nariño, Colombia. Simulación de antenas fotoconductoras para radiación terahertzġCarlos Criollo Paredes. Simulation of photoconductive antennas for terahertz radiation Esta simulación es útil para el diseño e implementación de antenas fotoconductoras como emisores de THz de diseño compacto y bajo costo. ![]() ![]() La emisión de Terahertz (THz) empleando antenas fotoconductoras representa un reto de simulación en la integración de los fenó-menos de transporte en semiconductores, de óptica y de transporte de energía por radiación THz. One of those techniques is dynamic bytecode instrumentation, which is particularly useful for profiling large Java applications. That research uncovered specific techniques that can be used to lower the overhead of profiling a Java application. The Profiler is based on a Sun Laboratories research project that was named JFluid. Formerly downloaded separately, it is integrated into the core IDE since version 6.0. The NetBeans Profiler is a tool for the monitoring of Java applications: It helps developers find memory leaks and optimize speed. These modules are part of the NetBeans IDE: ![]() NetBeans 6.0 installation disc Integrated modules Oracle JavaScript Extension Toolkit, a modular, open source toolkit based on modern JavaScript, CSS3 and HTML5 design and development principles uses NetBeans as its preferred IDE.Oracle JDeveloper, an end-to-end development for Oracle's technology stack takes major subsystems from NetBeans.Oracle Developer Studio, a commercial C, C++, Fortran and Java development environment is 100% based on NetBeans.In an October 2016 interview with Gabriela Motroc, Oracle Vice President Bill Pataky stated that Oracle has a number of products that depend on NetBeans. Oracle has donated NetBeans Platform and IDE to the Apache Foundation where it underwent incubation and graduated as a top level project in April 2019. In October 2007, Sun announced that NetBeans would henceforth be offered under a dual license of the CDDL and the GPL version 2 licenses, with the GPL linking exception for GNU Classpath. Previously, from July 2006 through 2007, NetBeans IDE was licensed under Sun's Common Development and Distribution License (CDDL), a license based on the Mozilla Public License (MPL). License: The IDE is licensed under the Apache License 2.0. For instance, Sun Studio, Sun Java Studio Enterprise, and Sun Java Studio Creator from Sun Microsystems are all based on the NetBeans IDE. New features, such as support for other programming languages, can be added by installing additional modules. Modules also allow NetBeans to be extended. NetBeans contains all the modules needed for Java development in a single download, allowing the user to start working immediately. Each module provides a well-defined function, such as support for the Java language, editing, or support for the CVS versioning system, and SVN. Modularity: All the functions of the IDE are provided by modules. Among other features are an Ant-based project system, Maven support, refactorings, version control (supporting CVS, Subversion, Git, Mercurial and Clearcase). NetBeans IDE supports development of all Java application types ( Java SE (including JavaFX), Java ME, web, EJB and mobile applications) out of the box. ![]() ![]() NetBeans IDE is an open-source integrated development environment. The project entered the Apache Incubator in October 2016. The move was endorsed by Java creator James Gosling. In September 2016, Oracle submitted a proposal to donate the NetBeans project to The Apache Software Foundation, stating that it was "opening up the NetBeans governance model to give NetBeans constituents a greater voice in the project's direction and future success through the upcoming release of Java 9 and NetBeans 9 and beyond". Under Oracle, NetBeans had to find some synergy with JDeveloper, a freeware IDE that has historically been a product of the company, by 2012 both IDEs were rebuilt around a shared codebase - the NetBeans Platform. In 2010, Sun (and thus NetBeans) was acquired by Oracle Corporation. ![]() Since then, the NetBeans community has continued to grow. Sun open-sourced the NetBeans IDE in June of the following year. In 1997, Roman Staněk formed a company around the project and produced commercial versions of the NetBeans IDE until it was bought by Sun Microsystems in 1999. NetBeans began in 1996 as Xelfi (word play on Delphi), a Java IDE student project under the guidance of the Faculty of Engineering and Technology at Charles University in Prague. ![]() You can even download it, share it as a PDF or convert it into a GIF!įlipbooks are a great option for those who don’t have the time or money to spend dozens of hours trying to make a functional website and optimize it for search engines. Using this format for your digital portfolio is simple, easy, and inexpensive. A homey design portfolio, courtesy of Lauren HomĪnother excellent way to show your work is an interactive flipbook. Animators, illustrators, 3D modelers, and web designers often choose this medium to display their skills, using the medium’s interactivity as a display piece. Web-based portfolios are preferred by designers whose work exceeds the limitations of other formats. Tools such as Wix and Squarespace have made this option much more viable in recent years, even for those without web design experience. Most artists these days opt for the portfolio website option, which provides several advantages compared to other competing mediums. While the format of your portfolio shouldn’t be your primary focus, choosing a medium that compliments your body of work doesn’t hurt. Here are other tips from professional graphic designers to help you get started. Don’t make the fit and finish of your portfolio format your focus instead, prioritize selecting the suitable projects to demonstrate your skills. The most important thing to remember is that your portfolio is simply a medium for you to display your work. How can you make a portfolio of your own? Now that you have a workable idea of what a graphic design portfolio looks like, it’s time to talk turkey. With a small but undeniably tasteful collection of projects, it shouldn’t take you more than a few seconds to be sold on her skills as a visual artist and graphic designer. Linda’s portfolio is a veritable masterclass in the school of less is more. While it might not be as in-your-face as the previous entry on our list of graphic design portfolio examples, the subdued but distinctively charming qualities of Linda Baritski and her work are immediately recognizable when viewing her portfolio. Skills displayed: illustration, animation, product branding. See what you can learn from these graphic design portfolio examples! Jane Song Minimlistic design portfolio, courtesy of Jane Songįormat: single-page website with individual project pages.Īesthetics: charming, line drawn, cartoonish. ![]() With years of experience and hundreds of projects under their belts, these graphic designers have proven that they have what it takes to secure contracts and make the art they want. Keep an eye out for how these artists put our tips into practice! Graphic design portfolio examples Now that you know what to look for let’s look at the portfolios of some of the most famous graphic designers working today.
However, most include these core components:Īnyone can use Gantt chart templates to track and show off their plans. The elements of a Gantt chart template can vary depending on the intended use case and level of detail being shown. What are the essential parts of a Gantt chart template? But they can be helpful anytime you want to visualize the details of planned work - like strategy, product releases, and other major projects. Gantt chart templates are most often used in the planning stage of the product development process. When should Gantt charts templates be used in product development? When plans or dates change, you need to be able to adjust your Gantt chart quickly and easily.įrequently asked questions about Gantt chart templates Gantt charts can quickly become too complex - especially if you are managing multiple products or projects in one sheet without advanced filtering options.Ĭhoose a Gantt chart template or tool that is simple to modify. Since Gantt charts are based on schedules and timelines, they are only useful if they convey accurate dates. Here are some best practices to keep in mind: In order to create the most effective Gantt charts, you need to feel confident about your approach to building, using, and maintaining your own Gantt sheets. But they lose their potency as soon as they become inaccurate, outdated, or overly complicated. Related: Gantt charts and kanban boards - what are they good for?Ĭommon pitfalls when creating Gantt charts ![]() ![]() Use a roadmap to capture the high-level strategy and a Gantt chart to show a more detailed view of the work - the phases, tasks, and milestones that the product and engineering teams must complete to achieve that strategy. But it is important to understand that both roadmaps and Gantt charts can actually be valuable (and even complementary) tools. This is why many agile teams use roadmaps instead of Gantts to visualize and communicate upcoming plans. Some teams that follow agile software methodology view Gantt charts as a relic of waterfall. Consider using a Gantt chart if you are:Ī business leader defining a company strategy, refreshing a business plan, or planning to enter a new market.Ī product manager planning product releases and features.Ī product marketer coordinating cross-functional plans to launch a new product or release new functionality to market.Ī project manager working with development teams to deliver product requirements on a set schedule Gantt charts are also useful for planning any type of time-driven or collaborative effort. This is why business leaders, product managers, and project managers commonly use Gantt calendars and diagrams - to give cross-functional teams an overview of upcoming work and align everyone around the timing of the plan. The success of any new product development process relies on a clear plan that everyone can rally behind. The two Excel downloads are less robust than the guided template but can be useful if you are just getting started and still making manual updates. This Gantt-style template helps you quickly show the "what" and "when" of your release plans - so everyone on the team understands exactly what is needed to deliver on schedule. The first example is a expert-crafted, guided template available in Aha! software. You can also show dependencies between tasks. You can track the status of each task by changing the color of the bar. This Gantt chart shows the key activities that make up the overall release plan, including the features that will be delivered. ![]() Gantt charts show all the phases of work required from all teams involved to meet a release deadline - serving as a more detailed companion to the product roadmap, which typically displays the general timeline for multiple releases. In fact, release planning is one of the most common use cases for Gantt charts in product development. Release planning Gantt charts are great tools for product managers. |
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